What Is Buclizine Hydrochloride? Composition, Mechanism & Medical Uses Table of Contents The antiemetic and sedative
Blog
By riya
December 12, 2025
What Is Buclizine Hydrochloride? Composition, Mechanism & Medical Uses
By riya
December 12, 2025
What Is Buclizine Hydrochloride? Composition, Mechanism & Medical Uses
Table of Contents
The antiemetic and sedative Buclizine Hydrochloride (HCl) has been extensively researched for many years. Although it may not be as well-known as other prescription drugs, it still has many useful applications within certain specialized fields of medicine.
In this blog, an overview of Buclizine Hydrochloride is presented that examines its active ingredient; chemical structure; effects on the body; and those situations in which a doctor might prescribe it.
What Is Buclizine Hydrochloride?
Buclizine Hydrochloride is an H1 (histamine) receptor antagonist belonging to the piperazine class of antihistamines. Histamines are produced by the body’s immune system to create allergic symptoms such as a runny nose or sneezing; in addition, they can be involved in several neurological processes.
Buclizine HCl is not an antihistamine used to alleviate allergic symptoms and is most commonly administered as an antiemetic (to inhibit vomiting) along with the treatment of nausea, vertigo, and vomiting caused by problems in the inner ear. The drug usually comes as a tablet or syrup and is administered orally.
Composition of Buclizine Hydrochloride
The active ingredient in this medication is Buclizine Hydrochloride.
The primary component of this product is Buclizine Hydrochloride. Along with active components, this product may contain other components that were manufactured and formulated to create an inactive ingredient list. The following inactive components may be listed on the package insert:
- Lactose or starch (as fillers)
- Magnesium stearate (as a lubricant)
- Talc or cellulose (for tablet structure)
- Flavoring agents (in syrups)
How Does Buclizine Hydrochloride Work? (Mechanism of Action)
To get a better understanding of the way Buclizine Hydrochloride functions, you should first understand how nausea/vomiting/dizziness occurs.
Role of Histamine and the Inner Ear
Symptoms of nausea and vomiting as well as dizziness can occur from an over-stimulation within the vestibular (inner ear) part of your brain and body that sends signals to the rest of your body about your surroundings, and where you are; however when this signals over-stimulates you, it has caused nausea, vomiting, dizziness, and even vertigo (a false sense of spinning or moving) which can be caused by a variety of different factors. One of the key hormones within this system that sends signals about movement and location is histamine.
Buclizine’s Action in the Body
Buclizine Hydrochloride inhibits H1 histamine receptors in addition to lowering the activity of the vestibular nervous system and decreasing the number of impulses being sent to the vomiting area of the brain. This causes a decrease in the sense of spinning and imbalance, as well as nausea and vomiting, and also helps with the discomfort caused by motion sickness. A mild sedative action adds to the calming effect of Buclizine on the nervous system when a patient is experiencing vertigo or motion sickness.
Medical Uses of Buclizine Hydrochloride
There are many medical uses for Buclizine Hydrochloride. Most commonly it is prescribed for nausea and for balance-related disorders.
1. Motion Sickness
The most widely recognized use of Buclizine Hydrochloride is in the management and treatment of motion sickness. In addition to car sickness, sea sickness, and other symptoms related to air travel, Buclizine Hydrochloride is frequently taken prior to travel to help prevent the occurrence of motion sickness.
2. Vertigo and Balance Disorders
Vertigo occurs when an individual perceives an exaggerated version of his or her own motion or an illusion of movement. Buclizine Hydrochloride is commonly used to improve the comfort and balance of individuals suffering from vertigo due to inner ear disorders, vestibular dysfunction, or Meniere’s disease.
3. Nausea and Vomiting
Buclizine Hydrochloride is effective in treating nausea and vomiting that arise due to vestibular disturbances, following surgery, or due to particular medical issues associated with the central nervous system; occasionally it is prescribed in cases of nausea.
4. Migraine-Associated Dizziness
Dizziness or vertigo are common symptoms experienced during a migraine attack, and buclizine Hydrochloride may provide symptomatic relief; however, buclizine Hydrochloride is not intended as a treatment for migraines themselves.
Final Thoughts
Buclizine Hydrochloride is a well-known and well-used medication that treats nausea, vomiting, motion sickness, and dizziness due to vestibular (balance) disorders. The medication relieves symptoms caused by the interruption of normal functions within the vestibular system (the organ of balance in the inner ear) and by blocking histamine from affecting certain receptors in the body.
If a doctor prescribes Buclizine Hydrochloride it is usually safe, however; it is very important to obtain your prescription from a licensed healthcare provider to reduce the risk of possible negative impacts and interactions with other medications you may be on.
Disclaimer: The above information has been provided as a general resource only and is not to be used in place of medical advice from a qualified healthcare professional. You should consult your physician regarding the use of this medication or any medications you might wish to try.
FAQs
What is Buclizine Hydrochloride used for?
Buclizine Hydrochloride has been shown to be effective in treating motion sickness, vertigo (long term sensation of imbalance), nausea, vomiting and dizziness associated with problems with balance due to inner ear problems.
How does Buclizine Hydrochloride work?
Buclizine Hydrochloride works by blocking the signals from the digestive system to the brain that produce nausea, dizziness, and vomiting. The drug blocks the H1 receptor of histamine.
Does Buclizine Hydrochloride cause drowsiness?
Due to its sedative effects, Buclizine Hydrochloride may also result in mild to moderate drowsiness. Therefore, it is not advised to drive or operate heavy equipment while under the influence of this drug.
Can Buclizine Hydrochloride be taken daily?
Your healthcare provider will determine whether this medication is appropriate for you to take every day based on the condition being treated, the dosage you are prescribed and how long you will be taking it.
Is Buclizine Hydrochloride safe for children?
If you are treating a child for a condition that would warrant using Buclizine Hydrochloride, the amount they are prescribed should be determined by a healthcare provider.